Prof. Emmanuelle Passegué
How does cellular stress affect lifespan? Does donating blood cause more cellular replication? Reducing lifespan?
Come listen to Prof. Emmanuelle Passegué from UCSF share her interesting research on blood stem cells and how they can age us.
Prof Passegué earned her PhD degree from the University Paris XI, France and then performed two consecutive postdoctoral fellowships. She first trained as a mouse geneticist with Dr. Erwin Wagner at the Institute for Molecular pathology (IMP) in Vienna, Austria, and then as a stem cell biologist with Dr. Irv Weissman at Stanford University. She joined the UCSF faculty in 2006, where she is currently a Professor in the Department of Medicine, Division of Hematology Oncology with the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research.
The Passegué lab’s research focuses on understanding the general defense mechanisms used by hematopoietic (blood) stem cells (HSC) to protect blood production during the lifetime of an ever-changing organism. This fundamental question is central to tissue maintenance and regeneration, and has implications for every aspect of adult physiology ranging from response to stress, development of diseases and biology of aging. The lab is interested in identifying the mechanisms controlling HSC activity in normal and stress conditions, and in understanding how they are affected during disease development and in physiological aging. Their goal is to identify affected genes and pathways that could be used to develop new therapies to treat human diseases and help combat aging. Current projects investigate the role of apoptosis, autophagy, immune regulations, DNA repair mechanisms and changes in the bone marrow niche in HSC function. See more about the lab here.